Other
Vosoritide
Also called Voxzogo, BMN-111
per administration
A human trial worked out how much to take and how often, so a dosing schedule is shown.
Licensed as a medicine in the US and EU.
Work out your draw
These numbers are a starting point — change any of them.
- Concentration
- 0.13mg/mL
- Volume per draw
- 1.13mL
- Units to dial
- 113
- Doses per cartridge
- 2
Requested 1.125 mL
Requested 112.5
This is 112.5 units, past the 60-unit dial. Splitting it across administrations, or using less water to raise the concentration, brings it back into range.
112.5 units is between clicks. The nearest setting is 113, which delivers 150.7 mcg instead of 150 mcg.
Dial range varies by pen; 1–60 units is the common configuration.
Vial label
Copy this into your label printer.
Published research contexts for Vosoritide describe 150–600 mcg per administration. Descriptive only, not a recommendation.
About 28 minutes; one of the shortest here, so the curve is a series of spikes rather than an accumulating level.
A modified analog of C-type natriuretic peptide, licensed as a medicine in the US and EU. Dosing is weight-based at 15 mcg/kg once daily subcutaneously; the range shown is a representative absolute amount for roughly a 10–40 kg child, and the vial strengths (0.4, 0.56 and 1.2 mg) are the reconstituted product's, made up with the supplied diluent. The study (Savarirayan, Lancet 2020) measured growth velocity in children with achondroplasia.
Dosing schedule
How Vosoritide is commonly stepped up, for reference only.
These are commonly-discussed research protocols shared for educational reference. This is not medical advice and is not a substitute for guidance from a qualified professional.
| Phase | Amount | Frequency | Route |
|---|---|---|---|
| Weight-basedScaled to body weight; made up from a lyophilised vial with the supplied diluent. | 15 mcg/kg | Once daily | SubQ |
Modelled level — every day
1× is the peak after a single dose.
- Steady-state peak
- 0.98× single dose
- Time to steady state
- 2hours
- Administrations
- 7/ week
Read off the modelled curve, not an even-interval formula
About five half-lives
Where these numbers come from
- Savarirayan R et al., Lancet 2020;396:684Randomized study of 15 mcg/kg daily subcutaneous vosoritide versus placebo over 52 weeks, with a growth-velocity endpoint in achondroplasia research in children.