Skip to content

Metabolic

Pramlintide

Also called Symlin

InjectableEvidence ATwice a day
Half-life
0.8hours
Typical vial
1.5 / 2.7mg
Research amounts
15–120mcg

per administration

Common schedule
Twice a day
Tested in people

A human trial worked out how much to take and how often, so a dosing schedule is shown.

Licensed as a medicine in the US.

Work out your draw

These numbers are a starting point — change any of them.

3 mL cartridge · 200 units loaded2units dialled
Concentration
0.75mg/mL
Volume per draw
0.02mL
Units to dial
2
Doses per cartridge
100

Vial label

Copy this into your label printer.

Published research contexts for Pramlintide describe 15120 mcg per administration. Descriptive only, not a recommendation.

About 48 minutes; an amylin analog given at meals, so the curve is a series of short spikes rather than an accumulating level.

Dosing schedule

How Pramlintide is commonly stepped up, for reference only.

These are commonly-discussed research protocols shared for educational reference. This is not medical advice and is not a substitute for guidance from a qualified professional.

PhaseAmountFrequencyRoute
Starting stepType-2 dosing in Hollander 2003; a separate injection site from any mealtime insulin.60 mcgBefore major mealsSubQ
MaintenanceType-1 use starts lower, 15 mcg titrated to 30–60 mcg.120 mcgBefore major mealsSubQ

Modelled level — twice a day

1× is the peak after a single dose.

Steady-state peak
1.00× single dose

Read off the modelled curve, not an even-interval formula

Time to steady state
4hours

About five half-lives

Administrations
14/ week

Where these numbers come from

  • Hollander PA et al., Diabetes Care 2003;26:784An amylin analog; dosing before major meals over a year improved long-term glycaemic and weight measures in adults with type-2 diabetes on insulin.

Next steps