Cognitive
PE-22-28
per administration
Only animal or lab studies exist — no human study has set an amount.
Work out your draw
These numbers are a starting point — change any of them.
- Concentration
- 1.67mg/mL
- Volume per draw
- 0.06mL
- Units to dial
- 6
- Doses per cartridge
- 50
Vial label
Copy this into your label printer.
Published research contexts for PE-22-28 describe 100–300 mcg per administration. Descriptive only, not a recommendation.
Spadin itself clears within minutes; the PE 22-28 analog was engineered for greater stability, but human pharmacokinetics are unpublished, so this is a rough placeholder.
Evidence is preclinical: a shortened, stabilised analog of spadin that blocks the TREK-1 potassium channel, studied in rodent mood and neurogenesis models. No human dose-ranging data fixes an amount or schedule and the figures are community-derived, so no schedule table is shown.
Modelled level — every day
1× is the peak after a single dose.
- Steady-state peak
- 1.00× single dose
- Time to steady state
- 5hours
- Administrations
- 7/ week
Read off the modelled curve, not an even-interval formula
About five half-lives
Where these numbers come from
- PE 22-28 / spadin TREK-1 literature (Mazella/Borsotto)A spadin-derived TREK-1 blocker reported to raise neurogenesis and antidepressant-like activity in mice; no human dosing literature.