Growth hormone axis
MK-677
Also called Ibutamoren, Nutrobal, L-163191
per administration
A human trial worked out how much to take and how often, so a dosing schedule is shown.
The human evidence for MK-677 used the oral route. The draw worked out here assumes a subcutaneous injection, so the amount is not a direct read-across.
Work out your draw
These numbers are a starting point — change any of them.
- Concentration
- 8.33mg/mL
- Volume per draw
- 3mL
- Units to dial
- 300
- Doses per cartridge
- 1
This is 300 units, past the 60-unit dial. Splitting it across administrations, or using less water to raise the concentration, brings it back into range.
Dial range varies by pen; 1–60 units is the common configuration.
Vial label
Copy this into your label printer.
Published research contexts for MK-677 describe 25–25 mg per administration. Descriptive only, not a recommendation.
About 4–6 hours; taken as a once-daily oral capsule.
An orally active growth-hormone secretagogue taken as a once-daily capsule; the 25 mg figure shown is a nominal oral capsule strength, not a vial. The human evidence is oral, so no injected schedule is shown.
Modelled level — every day
1× is the peak after a single dose.
- Steady-state peak
- 1.07× single dose
- Time to steady state
- 30hours
- Administrations
- 7/ week
Read off the modelled curve, not an even-interval formula
About five half-lives
Where these numbers come from
- Chapman IM et al., JCEM 1996;81:4249Daily oral MK-677 25 mg raised growth hormone and IGF-1 in healthy older volunteers over months.