Growth hormone axis
Macimorelin
Also called Macrilen, Ghryvelin
per administration
A human trial worked out how much to take and how often, so a dosing schedule is shown.
Licensed as a medicine in the US and EU.
The human evidence for Macimorelin used the oral route. The draw worked out here assumes a subcutaneous injection, so the amount is not a direct read-across.
Work out your draw
These numbers are a starting point — change any of them.
- Concentration
- 20mg/mL
- Volume per draw
- 1.75mL
- Units to dial
- 175
- Doses per cartridge
- 1
This is 175 units, past the 60-unit dial. Splitting it across administrations, or using less water to raise the concentration, brings it back into range.
Dial range varies by pen; 1–60 units is the common configuration.
Vial label
Copy this into your label printer.
Published research contexts for Macimorelin describe 35–35 mg per administration. Descriptive only, not a recommendation.
About 4 hours; a single oral dose, so the curve here is illustrative.
An oral peptidomimetic secretagogue given as a single 0.5 mg/kg dose (about 35 mg for a 70 kg adult) as a pituitary challenge, licensed in the US and EU; the 60 mg figure shown is the oral packet strength, not a vial, and no injected schedule is established, so no schedule table is shown.
Modelled level — every day
1× is the peak after a single dose.
- Steady-state peak
- 1.02× single dose
- Time to steady state
- 20hours
- Administrations
- 7/ week
Read off the modelled curve, not an even-interval formula
About five half-lives
Where these numbers come from
- Garcia JM et al., JCEM 2018;103:3083A single 0.5 mg/kg oral dose used as a growth-hormone secretagogue challenge, validated against the insulin-tolerance challenge for adult growth-hormone deficiency.