Longevity

FOXO4-DRI

Also called FOXO4-D-Retro-Inverso

InjectableEvidence C3x per week

Half-life

2hours

Typical vial

5 / 10mg

Research amounts

1–5mg

per administration

Common schedule

3x per week

Animal or lab only

Only animal or lab studies exist — no human study has set an amount.

Work out your draw

These numbers are a starting point — change any of them.

Amount in the vialmgBacteriostatic water you addmLAmount per drawmgAmount unitDevice

Concentration: 1.67mg/mL
Volume per draw: 0.6mL
Units to dial: 60
Doses per cartridge: 5

Vial label

Copy this into your label printer.

Label nameDate you mixed itFormatFor 24 mm tape, or 1" x 2 1/8" die-cut stock such as Dymo 30336.

FOXO4-DRI  1.67 mg/mL
60 units = 1 mg
Recon 2026-09-17

Published research contexts for FOXO4-DRI describe 1–5 mg per administration. Descriptive only, not a recommendation.

A D-retro-inverso peptide built to resist proteases; no human pharmacokinetics is published, so this is an order-of-magnitude guess.

A senolytic peptide that disrupts the FOXO4–p53 interaction to clear senescent cells in animal and cell models; evidence is preclinical, with no human study fixing an amount or schedule, so no schedule table is shown.

Modelled level — 3x per week

1× is the peak after a single dose.

Steady-state peak: 1.00× single dose
Time to steady state: 10hours
Administrations: 3/ week

Where these numbers come from

FOXO4-DRI senolytic study (Baar MP et al., Cell 2017)A D-retro-inverso peptide that cleared senescent cells in aged mice; no human dosing exists.

Next steps

Plan FOXO4-DRI alongside other compounds Work out cost per draw