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Cognitive

Dihexa

Also called PNB-0408

InjectableEvidence CEvery day
Half-life
8hours
Typical vial
10 / 20mg
Research amounts
5–20mg

per administration

Common schedule
Every day
Animal or lab only

Only animal or lab studies exist — no human study has set an amount.

Work out your draw

These numbers are a starting point — change any of them.

3 mL cartridge · 300 units loaded150units dialled
Concentration
3.33mg/mL
Volume per draw
1.5mL
Units to dial
150
Doses per cartridge
2

This is 150 units, past the 60-unit dial. Splitting it across administrations, or using less water to raise the concentration, brings it back into range.

Dial range varies by pen; 1–60 units is the common configuration.

Vial label

Copy this into your label printer.

Published research contexts for Dihexa describe 520 mg per administration. Descriptive only, not a recommendation.

No human pharmacokinetics; rodent work reports oral activity and metabolic stability, so this is an order-of-magnitude placeholder, not a measured value.

Evidence is preclinical: an angiotensin IV–derived peptidomimetic studied in rodent memory and neurotrophic models. No human dose-ranging study fixes an amount or schedule and the circulating figures are community-derived, so no schedule table is shown.

Modelled level — every day

1× is the peak after a single dose.

Steady-state peak
1.14× single dose

Read off the modelled curve, not an even-interval formula

Time to steady state
40hours

About five half-lives

Administrations
7/ week

Where these numbers come from

  • Dihexa (PNB-0408) preclinical literature (McCoy/Harding)An angiotensin IV analog reported to promote synaptogenesis via HGF/c-Met in rodent and cell models; human dosing is unpublished.

Next steps