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Desmopressin

Also called DDAVP

InjectableEvidence ATwice a day
Half-life
3hours
Typical vial
1mg
Research amounts
1–4mcg

per administration

Common schedule
Twice a day
Tested in people

A human trial worked out how much to take and how often, so a dosing schedule is shown.

Licensed as a medicine in the US and EU.

Work out your draw

These numbers are a starting point — change any of them.

3 mL cartridge · 300 units loaded0units dialled
Concentration
0.33mg/mL
Volume per draw
0mL

Requested 0.003 mL

Units to dial
0

Requested 0.3

Doses per cartridge
0

This is under the smallest 1-unit click, so the device cannot deliver it. More water lowers the concentration and makes the setting larger.

Vial label

Copy this into your label printer.

Published research contexts for Desmopressin describe 14 mcg per administration. Descriptive only, not a recommendation.

Terminal plasma half-life about 2–3 h, though the antidiuretic effect outlasts the measured blood level.

Desmopressin (DDAVP), a synthetic analog of the antidiuretic hormone vasopressin acting at the V2 receptor, licensed as a medicine in the US and EU. It is supplied by several routes — a subcutaneous or intravenous injection, an oral tablet and a nasal spray — and the mass differs sharply between them because little of an oral or nasal dose reaches circulation: the parenteral amount is only about 1–4 mcg, against roughly 100–400 mcg oral and 10–40 mcg nasal. The schedule below is the subcutaneous route.

Dosing schedule

How Desmopressin is commonly stepped up, for reference only.

These are commonly-discussed research protocols shared for educational reference. This is not medical advice and is not a substitute for guidance from a qualified professional.

PhaseAmountFrequencyRoute
Parenteral routeThe injectable amount is far smaller than the oral (~100–400 mcg) or nasal (~10–40 mcg) routes, since little of those reaches circulation.1–4 mcgOnce or twice dailySubQ

Modelled level — twice a day

1× is the peak after a single dose.

Steady-state peak
1.07× single dose

Read off the modelled curve, not an even-interval formula

Time to steady state
15hours

About five half-lives

Administrations
14/ week

Where these numbers come from

  • Mannucci PM et al., Lancet 1977 (DDAVP)The deamino-D-arginine vasopressin analog raised factor VIII and von Willebrand factor after a single dose; a V2-receptor agonist licensed across central diabetes insipidus, nocturnal polyuria and bleeding-disorder indications.

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