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Metabolic

Cagrilintide

Also called AM833

InjectableEvidence AOnce a week
Half-life
180hours
Typical vial
5 / 10mg
Research amounts
0.3–4.5mg

per administration

Common schedule
Once a week
Tested in people

A human trial worked out how much to take and how often, so a dosing schedule is shown.

Work out your draw

These numbers are a starting point — change any of them.

3 mL cartridge · 300 units loaded18units dialled
Concentration
1.67mg/mL
Volume per draw
0.18mL
Units to dial
18
Doses per cartridge
16

Vial label

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Published research contexts for Cagrilintide describe 0.34.5 mg per administration. Descriptive only, not a recommendation.

About 7–8 days; a long-acting amylin analog dosed once weekly.

Dosing schedule

How Cagrilintide is commonly stepped up, for reference only.

These are commonly-discussed research protocols shared for educational reference. This is not medical advice and is not a substitute for guidance from a qualified professional.

PhaseAmountFrequencyRoute
Weeks 1–2Start of the escalation; the phase-2 trial ramped over roughly 20 weeks.0.3 mgOnce weeklySubQ
Weeks 3–40.6 mgOnce weeklySubQ
Weeks 5–61.2 mgOnce weeklySubQ
Weeks 7–82.4 mgOnce weeklySubQ
Week 9+Highest step in the phase-2 trial; reached only as tolerated.4.5 mgOnce weeklySubQ

Modelled level — once a week

1× is the peak after a single dose.

Steady-state peak
2.09× single dose

Read off the modelled curve, not an even-interval formula

Time to steady state
37.5days

About five half-lives

Administrations
1/ week

Where these numbers come from

  • Lau DCW et al., Lancet 2021;398:2160Phase-2 of once-weekly cagrilintide escalated across 0.3, 0.6, 1.2, 2.4 and 4.5 mg over about 20 weeks in adults with overweight or obesity.

Next steps